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PX-1 Research Chemical Substance.

PX-1, also known as 5F-APP-PICA and SRF-30, is formally known as(S)-N-(1-amino-1-oxo-3-phenylpropan-2-yl)-1-(5-fluoropentyl)-1H-indole-3-carboxamide. Its molecular formula is C23H26FN3O2It has an λmax of 216, 291 nM and a stability rating for two years.

PX-1 is a relatively new product, and is becoming popular as a replacement for AB-CHMINACA where any of the latter compound’s properties may be undesirable. It is considered a fairly powerful synthetic cannabinoid. Its Ki value is 1.0 nM for the central CB1 receptor and 2.6 nM for the peripheral CB2 receptor. PX-1 is derived from AM2201, and features a very PINACA-like upper chain, but the isopropyl group normally in the position is instead replaced with a benzyl group.

PX-1 is, like AB-CHMINACA, an indole-type synthetic cannabinoid, a family of related and often analogous compounds that have become well-known in recent years as the active ingredients in various types of marijuana replacements and ‘legal highs’, so care should be taken in their shipping and storage.

Special Characteristics of PX-1:

Human Effects

Dosages, presuming a lack of acquired tolerance

  • Threshold:  approx. 1 mg
  • Light: approx. 1.5 to 2 mg
  • Standard: 2 to 3 mg
  • Strong: 4 to 5 mg
  • Heavy: 6+ mg

Duration, one to two hours, as follows:

  • Onset: 15 to 20 minutes
  • Peak: 30 minutes to 1 hour
  • Offset: 15 to 20 minutes
  • Afterglow: 15 to 30 minutes

Cognitive effects

  • Enhanced mental state
  • Improved connectivity of thought
  • Altered time sense
  • Improved conceptual thinking
  • Slowed information processing
  • Reduced dream activity
  • Anxiety

Physical effects

  • Tactile hallucination
  • Mild sedative effect
  • Reduced motor control
  • Enhanced appetite
  • Dehydration

Legal Status

Has been illegal to distribute in China since on October 1th 2015.

Sweden Public Health Agency began efforts to classify PX-1 as a hazardous substance in 2014.

PX-1 can be found on the Fifth Schedule of the Misuse of Drugs Act in Singapore, and is illegal there.

For further information please visit Wikipedia page.