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Buy Sedatives from ChemistryOrg - What Are Sedatives.


Sedatives, often called tranquillises, are a category of pharmaceutical chemicals which tend to ease anxiety, calm or cause sleep when taken by or applied to patients.

At low doses, they typically sooth irritability and calm excited states. At higher doses (dosage varies widely depending on the chemical used) a sedative may produce side effects such as loss of coordination, slurred speech, poor reflexes and a loss in critical or judgment capacity.

Sedatives are frequently used recreationally, as their calming effect is often considered pleasant. Alcohol is a chief example of a sedative commonly used for recreational rather than medical purposes. Recreation use of sedatives often involves combining diffentclases of sedatives, but this can lead quickly to unconsciousness and death, as when combining alcohol and barbiturates.


Therapeutic Use of Sedatives

Sedatives are most often administered in order to relieve a patient’s anxiety, often before a surgery or other procedure is performed. Sedatives themselves do not usually relieve pain to any great degree, but they are often used side by side with analgesics or anaesthetics (pain killers). They are often administered before patients are anaesthetised, because that procedure cat itself cause anxiety.

Sedatives are also often called for before particularly anxiety-causing or uncomfortable procedures, such as colonoscopies. They also make it easier for patients to stay still for MRIs.


Misuse of Sedatives

Because many people find sedatives pleasurable, they are often misused. The most common classes of medical sedatives to be misused are the benzodiazepines and the barbiturates. People may first come in to contact with these substances for legitimate medical reasons – difficulty sleeping, high stress or anxiety levels and the like, but then become regular users and eventually addicts who are chemically or psychologically dependent on the substance in question.

Medical sedatives are often used by heroin users who cannot find their drug of choice, or more dangerously, to supplement its effects. Potent stimulant users may turn to sedatives to calm the anxiety and ‘jitteryness’ those drugs often cause.

As a result, overdoses of sedatives are common, and deadly. Almost one third of all drug-related deaths are barbiturate overdoses. Many of these are suicides, but many are the result of already impaired users taking more of a sedative than they realise, or when combined with alcohol and its well-known judgment-impairing effects combine with those of one or more other sedatives.

A study was done in 2011 which showed that hypnotics and other sedatives were a factor in a very high percentage of bad drug interactions (adverse drug events) even in a hospital setting. Nearly 5% of all ADEs which occurred within US hospitals in 2011 were caused by either a sedative or a hypnotic.

Another danger of sedatives is the so-called ‘paradoxical reaction’. A paradoxical reaction is an unusual response of an individual to a particular drug, often involving depression, suicidal thoughts, sudden and acute phobias, aggressive and even violent behaviours, and symptoms similar to psychosis. Such paradoxical reactions can occur in as many as 5% of all doses with sedatives, though most estimates are far lower.


Terminology – What is a ‘Sedative’, a ‘Tranquiliser’ or a ‘Hypnotic’?

Long ago, there was little need to differentiate between sedatives, hypnotics and other related types of chemicals. Today, our understanding of how these chemicals interact with chemoreceptors in the nervous system is much more exact, and we can group sedatives into several broad classes, each of which has smaller subclasses.

The anxiolytic class of sedatives are called such because they tend to reduce a user’s experience of anxiety.

A tranquiliser could be an antipsychotic (useful in treating psychosis) or an anxiolytic (see above).

A hypnotic (also called a soporific) puts the patient to sleep.

Of course, no classification system is perfect, and many chemical groups belong to two different classes. Benzodiazepines, for example, fall in to all three categories, and are just as much soporifics as they are antipsychotics and anxiolytics. 

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